Search on: ALKYLATING AGENTS 
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Descriptor English:   Alkylating Agents 
Descriptor Spanish:   Agentes Alquilantes 
Descriptor Portuguese:   Alquilantes 
Tree Number:   D27.505.519.124
D27.888.569.035
Definition English:   Highly reactive chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many are used as antineoplastic agents, but most are very toxic, with carcinogenic, mutagenic, teratogenic, and immunosuppressant actions. They have also been used as components in poison gases. 
History Note English:   66(64) 
Allowable Qualifiers English:  
administration & dosage adverse effects
agonists antagonists & inhibitors
analysis blood
cerebrospinal fluid chemistry
classification chemical synthesis
contraindications diagnostic use
economics history
immunology isolation & purification
metabolism pharmacology
pharmacokinetics poisoning
radiation effects supply & distribution
standards toxicity
therapeutic use urine
Record Number:   479 
Unique Identifier:   D000477 

Occurrence in VHL:
 

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